Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | OGA | O60502 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1000367 | 0.89 | MEN1 (0.48) | NPC1RAB9ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL998937 | 0.81 | ALDH1A1 (0.44) | NPC1RAB9ASMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL1002667 | 0.80 | SMN1; SMN2 (0.40) | NPC1RAB9ASMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL1000697 | 0.79 | OGA (0.43) | NPC1RAB9ASMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL1000146 | 0.79 | CNR1 (0.47) | NPC1RAB9ASMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL12314933 | 0.79 | SMN1; SMN2 (0.42) | NPC1RAB9ASMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL1002094 | 0.79 | SMN1; SMN2 (0.42) | NPC1RAB9ASMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL998918 | 0.78 | OGA (0.40) | NPC1RAB9ASMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL1000355 | 0.77 | SMN1; SMN2 (0.42) | NPC1RAB9ASMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL2606414 | 0.77 | ITK (0.38) | LCKJAK3NPSR1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2444397-A1 | Heteroaryl-ureas and their use as glucokinase activators | Novo Nordisk A/S (DK) | 2012-04-25 | — | — | EP | disclosed |