Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.85 |
| ▸ | LIFR | P42702 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2130730 | 0.93 | NR1H4 (0.85) | NR1H4LIFR | |
| SCHEMBL2129017 | 0.92 | NR1H4 (1.00) | NR1H4LIFR | |
| SCHEMBL2128934 | 0.87 | NR1H4 (1.00) | NR1H4LIFR | |
| SCHEMBL4830998 | 0.80 | NR1H4 (0.72) | NR1H4LIFR | |
| SCHEMBL4421519 | 0.78 | NR1H4 (0.75) | NR1H4LIFR | |
| SCHEMBL21624441 | 0.75 | NR1H4 (1.00) | NR1H4LIFR | |
| SCHEMBL4611112 | 0.75 | NR1H4 (0.79) | NR1H4LIFR | |
| SCHEMBL4840444 | 0.74 | NR1H4 (0.69) | NR1H4LIFR | |
| SCHEMBL4435141 | 0.74 | NR1H4 (0.73) | NR1H4LIFR | |
| SCHEMBL2129180 | 0.74 | NR1H4 (0.72) | NR1H4LIFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2084147-B1 | HETEROCYCLIC FXR BINDING COMPOUNDS | PHENEX PHARMACEUTICALS AG (DE) | 2012-04-25 | — | — | EP | disclosed |