Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.85 |
| ▸ | LIFR | P42702 | 2/20 | 0.58 |
| ▸ | PPARD | Q03181 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2128095 | 0.93 | NR1H4 (0.85) | NR1H4LIFR | |
| SCHEMBL2128934 | 0.92 | NR1H4 (1.00) | NR1H4LIFRPPARD | |
| SCHEMBL2129017 | 0.87 | NR1H4 (1.00) | NR1H4LIFR | |
| SCHEMBL4840354 | 0.80 | NR1H4 (0.73) | NR1H4LIFRPPARD | |
| SCHEMBL4831050 | 0.78 | NR1H4 (0.75) | NR1H4LIFR | |
| SCHEMBL28529145 | 0.76 | NR1H4 (1.00) | NR1H4LIFRPPARD | |
| SCHEMBL2129180 | 0.76 | NR1H4 (0.72) | NR1H4LIFR | |
| SCHEMBL28530824 | 0.76 | NR1H4 (1.00) | NR1H4LIFRPPARD | |
| SCHEMBL4429503 | 0.75 | NR1H4 (0.72) | NR1H4LIFRPPARD | |
| SCHEMBL28524554 | 0.74 | NR1H4 (1.00) | NR1H4LIFRPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2084147-B1 | HETEROCYCLIC FXR BINDING COMPOUNDS | PHENEX PHARMACEUTICALS AG (DE) | 2012-04-25 | — | — | EP | disclosed |
| US-20100184809-A1 | Heterocyclic FXR Binding Compounds | PHENEX PHARMACEUTICALS AG (DE) | 2010-07-22 | — | — | US | disclosed |
| EP-2084147-A1 | HETEROCYCLIC FXR BINDING COMPOUNDS | Phenex Pharmaceuticals AG (DE) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008025540-A1 | HETEROCYCLIC FXR BINDING COMPOUNDS | PHENEX PHARMACEUTICALS AG (DE) | 2008-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184809-A1 | Heterocyclic FXR Binding Compounds | NR1H4, NR1H2, NR1H3 | NR1H4 1/4885LIFR 1535/4885PPARD 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.