Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.40 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18909445 | 0.85 | CACNA2D1 (0.42) | CACNA2D1CACNA1BCACNB1CACNA1CPOLB | |
| SCHEMBL24521470 | 0.83 | CACNA2D1 (0.44) | CACNA2D1CACNA1BCACNB1CACNA1CPOLB | |
| SCHEMBL24521450 | 0.83 | CACNA2D1 (0.41) | HRH2HRH1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL26705105 | 0.83 | CACNA2D1 (0.49) | HRH2HRH1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL25571572 | 0.83 | CACNA2D1 (0.55) | HRH2HRH1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL22030475 | 0.81 | CNR1 (0.41) | CACNA2D1CACNA1BCACNB1CACNA1CPOLB | |
| SCHEMBL22030875 | 0.81 | KDM4E (0.54) | CACNA2D1CACNA1BCACNB1CACNA1CPOLB | |
| SCHEMBL22891216 | 0.79 | CACNA2D1 (0.46) | CACNA2D1CACNA1BCACNB1CACNA1CPOLB | |
| SCHEMBL25571574 | 0.79 | CACNA2D1 (0.42) | HRH2HRH1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL21430676 | 0.78 | ALDH1A1 (0.42) | POLBMAPTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3596072-B1 | PYRAZOLOCHLOROPHENYL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2022-06-22 | — | — | EP | disclosed |
| EP-3416967-B1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2022-02-09 | — | — | EP | disclosed |
| EP-3380474-B1 | JANUS KINASES INHIBITORS, COMPOSITIONS THEREOF AND USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-08-21 | — | — | EP | disclosed |