SCHEMBL2128551

SCHEMBL2128551

CCN(C[C@H]1CC[C@H](CC(=O)O)CC1)c1ccc(C(F)(F)F)cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1

nearest known ligand 0.43

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
CETP P11597 20/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL681102 0.99 CETP (0.43) CETP
Hydrochloric Acid SCHEMBL681101 0.99 CETP (0.43) CETP
SCHEMBL4827495 0.94 CETP (0.43) CETP
SCHEMBL4824438 0.93 CETP (0.39) CETP
Hydrochloric Acid SCHEMBL680175 0.93 CETP (0.42) CETP
Hydrochloric Acid SCHEMBL680176 0.93 CETP (0.42) CETP
Hydrochloric Acid SCHEMBL680747 0.93 CETP (0.39) CETP
Hydrochloric Acid SCHEMBL680748 0.93 CETP (0.39) CETP
SCHEMBL4828879 0.92 CETP (0.48) CETP
SCHEMBL20768084 0.92 CETP (0.48) CETP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8828438-B2 Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors and HMG-CoA reductase BEND RESEARCH, INC. (US) 2014-09-09 US claimed
US-20090118328-A1 Pharmaceutical Compositions Of Cholesteryl Ester Transfer Protein Inhibitors And Hmg-Coa Reductase BEND RESEARCH, INC. (US) 2009-05-07 US claimed
EP-1893178-A1 PHARMACEUTICAL COMPOSITIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG-CoA REDUCTASE INHIBITORS Pfizer Products Incorporated (US) 2008-03-05 EP claimed
US-7332514-B2 Dibenzylamine compound and medicinal use thereof JAPAN TOBACCO INC. (JP) 2008-02-19 US claimed
WO-2006129167-A1 PHARMACEUTICAL COMPOSITIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG-CoA REDUCTASE INHIBITORS PFIZER PRODUCTS INC. (US) 2006-12-07 WO claimed
US-9724362-B2 Pharmaceutical compositions comprising nanoparticles and a resuspending material BEND RESEARCH, INC. (US) 2017-08-08 US disclosed
US-9545384-B2 Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate BEND RESEARCH, INC. (US) 2017-01-17 US disclosed
EP-1844078-B1 PHARMACEUTICAL COMPOSITIONS WITH ENHANCED PERFORMANCE BEND RES INC (US) 2016-09-28 EP disclosed
EP-2231169-B1 PHARMACEUTICAL COMPOSITIONS COMPRISING NANOPARTICLES AND A RESUSPENDING MATERIAL BEND RES INC (US) 2016-05-04 EP disclosed
EP-2162120-B1 NANOPARTICLES COMPRISING A NON-IONIZABLE CELLULOSIC POLYMER AND AN AMPHIPHILIC NON-IONIZABLE BLOCK COPOLYMER BEND RES INC (US) 2016-05-04 EP disclosed
US-9265731-B2 Drying of drug-containing particles BEND RESEARCH, INC. (US) 2016-02-23 US disclosed
EP-1855652-B1 DRYING OF DRUG-CONTAINING PARTICLES BEND RES INC (US) 2015-12-02 EP disclosed
WO-2006129167-A1 PHARMACEUTICAL COMPOSITIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG-CoA REDUCTASE INHIBITORS PFIZER PRODUCTS INC. (US) 2006-12-07 WO disclosed
WO-2006082500-A1 DOSAGE FORMS PROVIDING CONTROLLED AND IMMEDIATE RELEASE OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND IMMEDIATE RELEASE OF HMG-COA REDUCTASE INHIBITORS PFIZER PRODUCTS INC. (US) 2006-08-10 WO disclosed
WO-2006082518-A1 PHARMACEUTICAL COMPOSITIONS WITH ENHANCED PERFORMANCE PFIZER PRODUCTS INC. (US) 2006-08-10 WO disclosed
WO-2006079921-A2 DRYING OF DRUG-CONTAINING PARTICLES PFIZER PRODUCTS INC. (US) 2006-08-03 WO disclosed
WO-2006079922-A2 FAST-DISINTEGRATING MICROPOROUS BINDER AND PROCESS FOR MAKING IT PFIZER PRODUCTS INC. (US) 2006-08-03 WO disclosed
WO-2006033002-A1 4-AMINO SUBSTITUTED-2-SUBSTITUTED-1,2,3,4-TETRAHYDROQUINOLINE COMPOUNDS PFIZER PRODUCTS INC. (US) 2006-03-30 WO disclosed
US-20060063803-A1 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds PFIZER INC 2006-03-23 US disclosed
WO-2005115330-A2 PHARMACEUTICAL COMPOSITIONS WITH ENHANCED PERFORMANCE PFIZER PRODUCTS INC. (US) 2005-12-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090118328-A1 Pharmaceutical Compositions Of Cholesteryl Ester Transfer Protein Inhibitors And Hmg-Coa Reductase CETP, HMGCR, MTTP CETP 1/4885
US-20060063803-A1 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds APOB, LDLR, CETP CETP 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.