Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.56 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.56 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.56 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.55 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 3/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21286133 | 1.00 | GRIA1 (0.56) | GRIA1GRIA2GRIA3GRIA4TAAR1 | |
| SCHEMBL29335774 | 1.00 | GRIA1 (0.56) | GRIA1GRIA2GRIA3GRIA4TAAR1 | |
| SCHEMBL3944328 | 0.79 | KDM4E (0.61) | GRIA1GRIA2GRIA3GRIA4TAAR1 | |
| SCHEMBL8737419 | 0.78 | CYP2A6 (0.50) | GRIA1GRIA2GRIA3GRIA4LOXL2 | |
| SCHEMBL2758516 | 0.78 | CYP2A6 (0.50) | GRIA1GRIA2GRIA3GRIA4LOXL2 | |
| SCHEMBL26205757 | 0.78 | CYP2A6 (0.50) | GRIA1GRIA2GRIA3GRIA4LOXL2 | |
| SCHEMBL21274670 | 0.78 | GRIA1 (0.54) | GRIA1GRIA2GRIA3GRIA4MEN1 | |
| SCHEMBL5877782 | 0.76 | GRIA4 (0.91) | GRIA1GRIA2GRIA3GRIA4CYP19A1 | |
| SCHEMBL21286252 | 0.76 | TAAR1 (0.54) | GRIA1GRIA2GRIA3GRIA4TAAR1 | |
| SCHEMBL31477148 | 0.76 | GRIA1 (0.47) | GRIA1GRIA2GRIA3GRIA4LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3752497-B1 | P300/CBP HAT INHIBITORS | CONSTELLATION PHARMACEUTICALS INC (US) | 2024-07-17 | — | — | EP | disclosed |
| WO-2021021893-A1 | COMPOUNDS FOR USE IN TREATING NEUROLOGICAL DISORDERS | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2021-02-04 | — | — | WO | disclosed |
| WO-2019161162-A1 | P300/CBP HAT INHIBITORS | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2019-08-22 | — | — | WO | disclosed |