Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.61 |
| ▸ | BLM | P54132 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | HTR1A | P08908 | 2/20 | 0.61 |
| ▸ | THPO | P40225 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | NMUR2 | Q9GZQ4 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.61 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9647484 | 0.82 | HIF1A (0.49) | KDM4ETDP1HIF1ABLMALDH1A1 | |
| SCHEMBL6666064 | 0.80 | HIF1A (0.61) | KDM4ETDP1HIF1ABLMALDH1A1 | |
| SCHEMBL21285889 | 0.79 | GRIA1 (0.56) | KDM4ETDP1HIF1ABLMALDH1A1 | |
| SCHEMBL21286133 | 0.79 | GRIA1 (0.56) | KDM4ETDP1HIF1ABLMALDH1A1 | |
| SCHEMBL29335774 | 0.79 | GRIA1 (0.56) | KDM4ETDP1HIF1ABLMALDH1A1 | |
| SCHEMBL18245963 | 0.79 | LMNA (0.54) | KDM4EALDH1A1MAPTLOXL2GAA | |
| SCHEMBL2249403 | 0.79 | LMNA (0.54) | KDM4EALDH1A1MAPTLOXL2GAA | |
| SCHEMBL11980400 | 0.79 | CA12 (0.43) | KDM4EALDH1A1MAPTLOXL2GAA | |
| SCHEMBL3944322 | 0.77 | F2R (0.41) | KDM4ETDP1HIF1ABLMALDH1A1 | |
| Oxedrine SCHEMBL17726874 | 0.76 | KDM4E (1.00) | KDM4ETDP1HIF1ABLMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718632-B1 | PYRIMIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SANOFI AVENTIS (FR) | 2009-04-22 | — | — | EP | claimed |
| US-20040116464-A1 | Aryl-ethanolamine derivatives as antiviral agents | PHARMACIA & UPJOHN COMPANY | 2004-06-17 | — | — | US | disclosed |
| WO-2004022568-A1 | ARYL-ETHANOLAMINE DERIVATIVES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-03-18 | — | — | WO | disclosed |