SCHEMBL2128707

SCHEMBL2128707

COc1c(C(=O)NCCc2cccc(-c3ccc[nH]c3=O)c2)cccc1C(C)(C)C

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.45
NR1H4 Q96RI1 1/20 0.43
CDK4 P11802 3/20 0.41
CCND1 P24385 3/20 0.41
ABCG2 Q9UNQ0 3/20 0.40
ROCK2 O75116 2/20 0.39
ROCK1 Q13464 2/20 0.39
LMNA P02545 2/20 0.38
ALDH1A1 P00352 1/20 0.38
MAPT P10636 1/20 0.38
HPGD P15428 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
ESRRG P62508 1/20 0.38
MEN1 O00255 1/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
KMT2A Q03164 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1542669 0.85 CYP3A4 (0.54) CYP3A4ROCK2ROCK1LMNAALDH1A1
SCHEMBL1543036 0.81 CYP3A4 (0.48) CYP3A4KMT2A
SCHEMBL1542439 0.77 CYP3A4 (0.51) CYP3A4ROCK2ROCK1LMNAALDH1A1
SCHEMBL2127832 0.77 CYP3A4 (0.49) CYP3A4ALDH1A1HPGDSMN1; SMN2
SCHEMBL2127598 0.74 NR1H4 (0.40) CYP3A4NR1H4ROCK2ROCK1MEN1
SCHEMBL1542596 0.73 CYP3A4 (0.49) CYP3A4ROCK2ROCK1SMN1; SMN2MEN1
SCHEMBL1542874 0.73 CYP3A4 (0.51) CYP3A4NR1H4MAPTSMN1; SMN2NPC1
SCHEMBL1542823 0.72 CYP3A4 (0.50) CYP3A4NR1H4ROCK2ROCK1ALDH1A1
SCHEMBL1542545 0.72 SMYD2 (0.49) CYP3A4
SCHEMBL2128506 0.71 CYP3A4 (0.51) CYP3A4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2307372-B1 HETEROCYCLIC ANTIVIRAL COMPOUNDS HOFFMANN LA ROCHE (CH) 2012-04-25 EP claimed