SCHEMBL2129114

SCHEMBL2129114

c1ccc(-c2ncnc(-c3ccccc3)c2-c2ccccc2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 1/20 0.56
JAK2 O60674 1/20 0.48
ALOX15 P16050 1/20 0.44
PTGS1 P23219 2/20 0.43
PTGS2 P35354 2/20 0.43
LMNA P02545 3/20 0.42
MAPT P10636 2/20 0.42
HTT P42858 2/20 0.42
KDM4E B2RXH2 3/20 0.41
CYP3A4 P08684 1/20 0.41
ALDH1A1 P00352 5/20 0.40
MIF P14174 1/20 0.40
ASIC3 Q9UHC3 1/20 0.40
HPGD P15428 2/20 0.40
TNK2 Q07912 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
ATM Q13315 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
XDH P47989 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27908369 0.97 ADORA2A (0.54) ADORA2AJAK2ALOX15PTGS1PTGS2
SCHEMBL31452805 0.87 ADORA1 (0.47) ADORA2AJAK2HPGD
SCHEMBL31452816 0.87 LMNA (0.55) ADORA2AJAK2LMNAKDM4EALDH1A1
SCHEMBL10205904 0.84 ADORA2A (0.47) ADORA2AJAK2PTGS1PTGS2MAPT
SCHEMBL31452826 0.82 KDM4E (0.59) ADORA2APTGS2LMNAKDM4EALDH1A1
SCHEMBL31452833 0.82 PTGS1 (0.44) ADORA2AJAK2ALOX15PTGS1PTGS2
SCHEMBL14288873 0.80 ADORA2A (0.43) ADORA2AJAK2PTGS1PTGS2LMNA
SCHEMBL29086590 0.80 ADORA2A (0.43) ADORA2AJAK2ALOX15PTGS1PTGS2
SCHEMBL31452795 0.80 PIK3CA (0.49) ADORA2AJAK2PTGS1PTGS2MAPT
SCHEMBL4840266 0.78 KDM4E (0.50) ADORA2AJAK2LMNAMAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119735553-A Substituted pyrimidine compound and preparation method and application thereof 上海应用技术大学 2025-04-01 CN claimed
CN-119735553-A Substituted pyrimidine compound and preparation method and application thereof 上海应用技术大学 2025-04-01 CN disclosed
US-9985223-B2 Iridium organometallic complexes comprising 4-arylpyrimidines SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2018-05-29 US disclosed
US-9985223-B2 Iridium organometallic complexes comprising 4-arylpyrimidines SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2018-05-29 US disclosed
US-9985223-B2 Iridium organometallic complexes comprising 4-arylpyrimidines SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2018-05-29 US disclosed
CN-106083936-A Organometallic complex, light-emitting component, light-emitting device, electronic equipment and illuminator 株式会社半导体能源研究所 2016-11-09 CN disclosed
CN-103168043-B Organometallic complex, light-emitting element, light-emitting device, electronic device, and lighting device 株式会社半导体能源研究所 2016-08-03 CN disclosed
US-20160064678-A1 Organometallic Complex, Light-Emitting Element, Light-Emitting Device, Electronic Device and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-03-03 US disclosed
US-20160064678-A1 Organometallic Complex, Light-Emitting Element, Light-Emitting Device, Electronic Device and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-03-03 US disclosed
US-20160064678-A1 Organometallic Complex, Light-Emitting Element, Light-Emitting Device, Electronic Device and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-03-03 US disclosed
US-8921548-B2 4-arylpyrimidine derivative SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-12-30 US disclosed
US-8921548-B2 4-arylpyrimidine derivative SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-12-30 US disclosed
US-8921548-B2 4-arylpyrimidine derivative SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-12-30 US disclosed
CN-103254241-A Organometallic complex, light-emitting element, light-emitting device, electronic device and lighting device SEMICONDUCTOR ENERGY LAB 2013-08-21 CN disclosed
CN-103168043-A Organometallic complex, light-emitting element, light-emitting device, electronic device, and lighting device SEMICONDUCTOR ENERGY LAB 2013-06-19 CN disclosed
US-20120098417-A1 Organometallic Complex, Light-Emitting Element, Light-Emitting Device, Electronic Device and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-04-26 US disclosed
US-20120098417-A1 Organometallic Complex, Light-Emitting Element, Light-Emitting Device, Electronic Device and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-04-26 US disclosed
US-20120098417-A1 Organometallic Complex, Light-Emitting Element, Light-Emitting Device, Electronic Device and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-04-26 US disclosed
WO-2012053627-A1 ORGANOMETALLIC COMPLEX, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE AND LIGHTING DEVICE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2012-04-26 WO disclosed
WO-2012053627-A1 ORGANOMETALLIC COMPLEX, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE AND LIGHTING DEVICE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2012-04-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120098417-A1 Organometallic Complex, Light-Emitting Element, Light-Emitting Device, Electronic Device and Lighting Device NR2E3, IGF1R, GRIA1 ADORA2A 745/4885JAK2 2702/4885ALOX15 1616/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.