Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.44 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13986014 | 0.83 | TRPV1 (0.45) | TRPV1KCNN4NPC1MAPK1RAB9A | |
| SCHEMBL2130309 | 0.81 | KMT2A (0.46) | KCNN4NPC1MAPK1RAB9AALDH1A1 | |
| SCHEMBL10596969 | 0.81 | KCNN4 (0.62) | KCNN4NPC1MAPK1RAB9APTPN1 | |
| SCHEMBL470103 | 0.81 | CNR1 (0.47) | TRPV1KCNN4MAPK1CNR1CNR2 | |
| SCHEMBL4309547 | 0.80 | CA1 (0.50) | NPC1MAPK1RAB9AALDH1A1MAPT | |
| SCHEMBL4517779 | 0.79 | TRPV1 (0.43) | TRPV1HDAC1HDAC7HDAC8HDAC6 | |
| SCHEMBL31560823 | 0.75 | HDAC3 (0.42) | KCNN4NPC1RAB9ACFTRCNR1 | |
| SCHEMBL4715047 | 0.70 | LMNA (0.39) | TRPV1MAPK1CNR1CNR2ALDH1A1 | |
| SCHEMBL29024474 | 0.70 | PPARA (0.46) | TRPV1MAPK1RAB9ACNR1ALDH1A1 | |
| SCHEMBL19423364 | 0.70 | KCNN4 (0.34) | TRPV1KCNN4CNR1CNR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120101039-A1 | CALCIUM-SENSING RECEPTOR-ACTIVE COMPOUNDS | LEO PHARMA A/S (DK) | 2012-04-26 | — | — | US | disclosed |
| WO-2010136036-A2 | CALCIUM-SENSING RECEPTOR-ACTIVE COMPOUNDS | LEO PHARMA A/S (DK) | 2010-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101039-A1 | CALCIUM-SENSING RECEPTOR-ACTIVE COMPOUNDS | CASR, CALCR, PTH1R | TRPV1 29/4885KCNN4 136/4885NPC1 1391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.