⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10267681 | 0.76 | HSD17B10 (0.37) | — | |
| SCHEMBL681111 | 0.71 | — | — | |
| SCHEMBL5674859 | 0.67 | — | — | |
| SCHEMBL2616441 | 0.67 | AR (0.31) | — | |
| SCHEMBL20421284 | 0.67 | ALDH1A1 (0.34) | — | |
| SCHEMBL2957684 | 0.67 | — | — | |
| SCHEMBL3823255 | 0.66 | — | — | |
| SCHEMBL3387689 | 0.64 | KDM4E (0.37) | — | |
| SCHEMBL508438 | 0.64 | GBA1 (0.33) | — | |
| SCHEMBL13180191 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11008312-B2 | Pyridazine derivatives as RORc modulators | GENENTECH, INC. (US) | 2021-05-18 | — | — | US | disclosed |
| EP-3535255-A1 | PYRIDAZINE DERIVATIVES AS RORC MODULATORS | H. Hoffnabb-La Roche Ag (CH) | 2019-09-11 | — | — | EP | disclosed |
| US-20190263794-A1 | PYRIDAZINE DERIVATIVES AS RORc MODULATORS | GENENTECH, INC. (US) | 2019-08-29 | — | — | US | disclosed |