Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 7/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGAV | P06756 | 1/20 | 0.42 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.42 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22970326 | 1.00 | GPR139 (0.58) | GPR139MEN1KMT2ALMNAPOLB | |
| SCHEMBL25846583 | 0.89 | KCNK2 (0.48) | GPR139MEN1KMT2ALMNAPOLB | |
| SCHEMBL21288068 | 0.89 | KCNK2 (0.48) | GPR139MEN1KMT2ALMNAPOLB | |
| SCHEMBL21303100 | 0.88 | GPR139 (0.58) | GPR139MEN1KMT2ALMNAPOLB | |
| SCHEMBL21288036 | 0.88 | GPR139 (0.58) | GPR139MEN1KMT2ALMNAPOLB | |
| SCHEMBL21288075 | 0.87 | PDE2A (0.48) | GPR139MMEITGB3ITGAVITGB5 | |
| SCHEMBL21303092 | 0.87 | PDE2A (0.48) | GPR139MMEITGB3ITGAVITGB5 | |
| SCHEMBL21288072 | 0.86 | MEN1 (0.45) | GPR139MEN1KMT2ALMNAPOLB | |
| SCHEMBL21303094 | 0.86 | MEN1 (0.45) | GPR139MEN1KMT2ALMNAPOLB | |
| SCHEMBL21272691 | 0.85 | GPR139 (0.58) | GPR139MEN1KMT2ALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3755684-B1 | ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS | H LUNDBECK AS (DK) | 2023-07-12 | — | — | EP | disclosed |
| EP-3755684-A1 | ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS | H. Lundbeck A/S (DK) | 2020-12-30 | — | — | EP | disclosed |
| WO-2019161877-A1 | ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS | H. LUNDBECK A/S (DK) | 2019-08-29 | — | — | WO | disclosed |
| WO-2019161877-A1 | ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS | H. LUNDBECK A/S (DK) | 2019-08-29 | — | — | WO | disclosed |