Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGAV | P06756 | 2/20 | 0.41 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.41 |
| ▸ | ITGB6 | P18564 | 2/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | CTSA | P10619 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | CETP | P11597 | 2/20 | 0.39 |
| ▸ | UGCG | Q16739 | 1/20 | 0.39 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21295102 | 1.00 | GPR139 (0.46) | GPR139ITGB3ITGAVITGB5ITGB6 | |
| SCHEMBL16563388 | 0.86 | PDE2A (0.43) | ITGB3ITGAVPDE2A | |
| SCHEMBL21272633 | 0.85 | GPR139 (0.42) | GPR139PDE2AUGCG | |
| SCHEMBL21272631 | 0.85 | GPR139 (0.42) | GPR139PDE2AUGCG | |
| SCHEMBL29440427 | 0.85 | GPR139 (0.42) | GPR139PDE2AUGCG | |
| SCHEMBL21272738 | 0.84 | GPR139 (0.44) | GPR139ITGB3ITGAVITGB5ITGB6 | |
| SCHEMBL21288050 | 0.84 | GPR139 (0.44) | GPR139ITGB3ITGAVITGB5ITGB6 | |
| SCHEMBL29589628 | 0.84 | GPR139 (0.44) | GPR139ITGB3ITGAVITGB5ITGB6 | |
| SCHEMBL21303101 | 0.84 | GPR139 (0.44) | GPR139ITGB3ITGAVITGB5ITGB6 | |
| SCHEMBL21272741 | 0.84 | GPR139 (0.44) | GPR139ITGB3ITGAVITGB5ITGB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3755684-A1 | ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS | H. Lundbeck A/S (DK) | 2020-12-30 | — | — | EP | disclosed |
| WO-2019161877-A1 | ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS | H. LUNDBECK A/S (DK) | 2019-08-29 | — | — | WO | disclosed |