Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.75 |
| ▸ | POLB | P06746 | 2/20 | 0.75 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.66 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.66 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.66 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17552186 | 0.91 | KMT2A (0.74) | TP53POLBCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL29831356 | 0.91 | KMT2A (0.74) | TP53POLBCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL29911013 | 0.84 | POLB (0.62) | TP53POLBKMT2AMAPTNPC1 | |
| SCHEMBL17552175 | 0.84 | POLB (0.62) | TP53POLBKMT2AMAPTNPC1 | |
| SCHEMBL26798520 | 0.81 | MAPT (0.64) | TP53POLBKMT2AMAPTNPC1 | |
| SCHEMBL29419544 | 0.81 | MAPT (0.73) | TP53POLBKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL29911029 | 0.81 | MAPT (0.73) | TP53POLBKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL17552230 | 0.81 | MAPT (0.73) | TP53POLBKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL29911092 | 0.81 | TP53 (0.64) | TP53POLBKMT2AMAPTHSD17B10 | |
| SCHEMBL17552181 | 0.81 | TP53 (0.64) | TP53POLBKMT2AMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3755434-A1 | TREATMENT FOR AGE- AND OXIDATIVE STRESS-ASSOCIATED MUSCLE ATROPHY AND WEAKNESS | Oklahoma Medical Research Foundation (US) | 2020-12-30 | — | — | EP | disclosed |
| WO-2019164597-A1 | TREATMENT FOR AGE- AND OXIDATIVE STRESS-ASSOCIATED MUSCLE ATROPHY AND WEAKNESS | OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) | 2019-08-29 | — | — | WO | disclosed |