SCHEMBL21295847

SCHEMBL21295847

[c]1cccc(-c2ccc3ncccc3c2)c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.68
POLB P06746 2/20 0.68
RAB9A P51151 2/20 0.68
DYRK1A Q13627 1/20 0.55
MCL1 Q07820 1/20 0.48
MAPT P10636 4/20 0.46
ALDH1A1 P00352 3/20 0.46
ATM Q13315 2/20 0.46
HTT P42858 2/20 0.46
KDM4E B2RXH2 1/20 0.46
TP53 P04637 1/20 0.46
HSP90AA1 P07900 1/20 0.46
HSP90AB1 P08238 1/20 0.46
TSHR P16473 1/20 0.46
CASP1 P29466 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
HSD17B10 Q99714 1/20 0.46
GSK3B P49841 1/20 0.43
GRM4 Q14833 1/20 0.41
CYP2A6 P11509 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21295643 0.87 NPC1 (0.49) NPC1POLBRAB9ADYRK1AALDH1A1
SCHEMBL29757180 0.82 NPC1 (1.00) NPC1POLBRAB9ADYRK1AMCL1
SCHEMBL30743 0.82 NPC1 (1.00) NPC1POLBRAB9ADYRK1AMCL1
SCHEMBL28167298 0.81 NPC1 (0.75) NPC1POLBRAB9ADYRK1AMCL1
SCHEMBL28603581 0.81 ALDH1A1 (0.48) NPC1POLBRAB9ADYRK1AMAPT
SCHEMBL443618 0.79 NPC1 (0.84) NPC1POLBRAB9ADYRK1AMCL1
SCHEMBL12075055 0.79 NPC1 (0.84) NPC1POLBRAB9ADYRK1AMCL1
SCHEMBL30592751 0.79 NPC1 (0.84) NPC1POLBRAB9ADYRK1AMCL1
SCHEMBL28135502 0.79 CCR1 (0.42) NPC1POLBRAB9ADYRK1AMAPT
SCHEMBL7260960 0.79 CYP2A6 (0.57) GRM4CYP2A6CYP1A2PIK3CDPIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109311844-B Triazine compound, method for producing same, and organic electroluminescent element containing same as constituent component 东曹株式会社 2021-07-20 CN disclosed
CN-112912372-A Cyclic azine compound, material for organic electroluminescent element, electron transport material for organic electroluminescent element, and organic electroluminescent element 东曹株式会社 2021-06-04 CN disclosed
WO-2020085319-A1 CYCLIC AZINE COMPOUND, MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENTS, ELECTRON TRANSPORT MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENTS, AND ORGANIC ELECTROLUMINESCENT ELEMENT 東ソー株式会社 2020-04-30 WO disclosed
WO-2019163959-A1 CYCLIC AZINE COMPOUND, MATERIAL FOR ORGANIC ELECTROLUMINESCNET ELEMENT, AND ELECTRON-TRANSPORTING MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENT 東ソー株式会社 2019-08-29 WO disclosed
CN-109311844-A Triaizine compounds, its manufacturing method and the organic electroluminescent device as constituent 东曹株式会社 2019-02-05 CN disclosed
CN-106573912-A Triazine compound, method for producing same, and application for same 东曹株式会社 2017-04-19 CN disclosed