Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20238304 | 0.75 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2KMT2AAPOBEC3GKDM4E | |
| SCHEMBL28093349 | 0.75 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2KMT2AAPOBEC3GPKM | |
| SCHEMBL1094470 | 0.75 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2KMT2AAPOBEC3GPKM | |
| SCHEMBL28335411 | 0.75 | GRM4 (0.45) | ALDH1A1SMN1; SMN2KMT2AF2GRM4 | |
| SCHEMBL1094424 | 0.75 | APOBEC3G (0.47) | ALDH1A1SMN1; SMN2KMT2AAPOBEC3GPKM | |
| SCHEMBL3297940 | 0.61 | SLC6A2 (0.40) | ALDH1A1KMT2APKMHSP90AA1KDM4E | |
| SCHEMBL10834133 | 0.61 | SLC6A2 (0.38) | HSP90AA1 | |
| SCHEMBL21925687 | 0.61 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2KMT2AHSP90AA1KDM4E | |
| Formic Acid SCHEMBL21296527 | 0.60 | POLB (0.49) | ALDH1A1SMN1; SMN2KDM4EHPGDHSD17B10 | |
| SCHEMBL27655831 | 0.60 | HSP90AA1 (0.40) | HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3759098-A1 | PYRIDINE-SULFONAMIDE COMPOUNDS AND THEIR USE AGAINST PAIN AND RELATED CONDITIONS | Genentech, Inc. (US) | 2021-01-06 | — | — | EP | disclosed |
| WO-2019165290-A1 | PYRIDINE-SULFONAMIDE COMPOUNDS AND THEIR USE AGAINST PAIN AND RELATED CONDITIONS | GENENTECH, INC. (US) | 2019-08-29 | — | — | WO | disclosed |