Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 11/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20063931 | 1.00 | HTR2C (0.49) | HTR2CSCN9ADRD2HTR2AHTR2B | |
| SCHEMBL23140876 | 0.89 | SCN9A (0.46) | HTR2CSCN9ADRD2HTR2AHTR2B | |
| SCHEMBL23140942 | 0.88 | DRD2 (0.47) | HTR2CSCN9ADRD2HTR2AHTR2B | |
| SCHEMBL21294827 | 0.87 | HTR2C (0.44) | HTR2CSCN9ADRD2 | |
| SCHEMBL23140860 | 0.86 | DRD2 (0.51) | HTR2CSCN9ADRD2HTR2AHTR2B | |
| SCHEMBL23140999 | 0.86 | DRD2 (0.51) | HTR2CSCN9ADRD2HTR2AHTR2B | |
| SCHEMBL20063390 | 0.85 | SCN9A (0.51) | HTR2CSCN9A | |
| SCHEMBL20063859 | 0.84 | HTR2C (0.49) | HTR2CSCN9ADRD2HTR2AHTR2B | |
| SCHEMBL20063858 | 0.84 | HTR2C (0.49) | HTR2CSCN9ADRD2HTR2AHTR2B | |
| SCHEMBL28491550 | 0.84 | HTR2C (0.49) | HTR2CSCN9ADRD2HTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3759098-A1 | PYRIDINE-SULFONAMIDE COMPOUNDS AND THEIR USE AGAINST PAIN AND RELATED CONDITIONS | Genentech, Inc. (US) | 2021-01-06 | — | — | EP | disclosed |
| WO-2019165290-A1 | PYRIDINE-SULFONAMIDE COMPOUNDS AND THEIR USE AGAINST PAIN AND RELATED CONDITIONS | GENENTECH, INC. (US) | 2019-08-29 | — | — | WO | disclosed |