Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | HTT | P42858 | 2/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | CLK1 | P49759 | 1/20 | 0.60 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | PABPC1 | P11940 | 3/20 | 0.57 |
| ▸ | EIF4H | Q15056 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21296571 | 0.89 | PTPN1 (0.60) | ALDH1A1LMNAHTTSMN1; SMN2MEN1 | |
| SCHEMBL4861658 | 0.88 | ALDH1A1 (0.70) | ALDH1A1LMNAHTTSMN1; SMN2MEN1 | |
| SCHEMBL8402846 | 0.85 | ALDH1A1 (0.74) | ALDH1A1LMNAHTTSMN1; SMN2MEN1 | |
| SCHEMBL29728211 | 0.85 | ALDH1A1 (1.00) | ALDH1A1LMNAHTTSMN1; SMN2MEN1 | |
| SCHEMBL4865337 | 0.85 | ALDH1A1 (1.00) | ALDH1A1LMNAHTTSMN1; SMN2MEN1 | |
| SCHEMBL6030648 | 0.85 | ALDH1A1 (0.74) | ALDH1A1LMNAHTTSMN1; SMN2MEN1 | |
| SCHEMBL6030652 | 0.85 | ALDH1A1 (0.74) | ALDH1A1LMNAHTTSMN1; SMN2MEN1 | |
| SCHEMBL27617527 | 0.85 | ALDH1A1 (0.74) | ALDH1A1LMNAHTTSMN1; SMN2MEN1 | |
| SCHEMBL3319628 | 0.84 | ALDH1A1 (0.64) | ALDH1A1LMNAHTTSMN1; SMN2MEN1 | |
| SCHEMBL2639029 | 0.82 | ALDH1A1 (0.70) | ALDH1A1LMNAHTTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11999731-B2 | EGFR dimer disruptors and use of the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-06-04 | — | — | US | disclosed |
| US-20220340572-A1 | EGFR DIMER DISRUPTORS AND USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2022-10-27 | — | — | US | disclosed |
| US-11358965-B2 | EGFR dimer disruptors and use of the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-06-14 | — | — | US | disclosed |
| EP-3755323-A1 | EGFR DIMER DISRUPTORS AND USE OF THE SAME | The Regents Of The University Of Michigan (US) | 2020-12-30 | — | — | EP | disclosed |
| US-20200377503-A1 | EGFR DIMER DISRUPTORS AND USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2020-12-03 | — | — | US | disclosed |
| CN-111886009-A | EGFR dimer disruptors and uses thereof | 密歇根大学董事会 | 2020-11-03 | — | — | CN | disclosed |
| WO-2019165358-A1 | EGFR DIMER DISRUPTORS AND USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11358965-B2 | EGFR dimer disruptors and use of the same | EGFR, ERBB2, ERBB4 | ALDH1A1 4429/4885LMNA 4402/4885HTT 3104/4885 |
| US-20220340572-A1 | EGFR DIMER DISRUPTORS AND USE OF THE SAME | EGFR, ERBB2, ERBB4 | ALDH1A1 4429/4885LMNA 4402/4885HTT 3104/4885 |
| US-11999731-B2 | EGFR dimer disruptors and use of the same | EGFR, ERBB2, ERBB4 | ALDH1A1 4429/4885LMNA 4402/4885HTT 3104/4885 |
| US-20200377503-A1 | EGFR DIMER DISRUPTORS AND USE OF THE SAME | EGFR, ERBB2, ERBB4 | ALDH1A1 4429/4885LMNA 4402/4885HTT 3104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.