Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.36 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30468550 | 0.86 | HSD17B10 (0.51) | APPS1PR3S1PR1PSEN1PSEN2 | |
| SCHEMBL28247029 | 0.86 | HSD17B10 (0.51) | APPS1PR3S1PR1PSEN1PSEN2 | |
| SCHEMBL12498905 | 0.86 | HSD17B10 (0.51) | APPS1PR3S1PR1PSEN1PSEN2 | |
| Hydrochloric Acid SCHEMBL2789847 | 0.84 | APP (0.42) | APPS1PR3S1PR1PSEN1PSEN2 | |
| Hydrochloric Acid SCHEMBL2834107 | 0.84 | HSD17B10 (0.50) | APPS1PR3S1PR1PSEN1PSEN2 | |
| SCHEMBL21296577 | 0.83 | TNF (0.47) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL12497587 | 0.82 | CES2 (0.45) | APPS1PR3S1PR1PSEN1PSEN2 | |
| SCHEMBL12499078 | 0.82 | CES2 (0.45) | APPS1PR3S1PR1PSEN1PSEN2 | |
| Hydrochloric Acid SCHEMBL4378356 | 0.81 | TNF (0.46) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11386312 | 0.80 | HSD17B10 (0.46) | APPMEN1KMT2ACYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11999731-B2 | EGFR dimer disruptors and use of the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-06-04 | — | — | US | disclosed |
| US-20220340572-A1 | EGFR DIMER DISRUPTORS AND USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2022-10-27 | — | — | US | disclosed |
| US-11358965-B2 | EGFR dimer disruptors and use of the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-06-14 | — | — | US | disclosed |
| EP-3755323-A1 | EGFR DIMER DISRUPTORS AND USE OF THE SAME | The Regents Of The University Of Michigan (US) | 2020-12-30 | — | — | EP | disclosed |
| US-20200377503-A1 | EGFR DIMER DISRUPTORS AND USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2020-12-03 | — | — | US | disclosed |
| CN-111886009-A | EGFR dimer disruptors and uses thereof | 密歇根大学董事会 | 2020-11-03 | — | — | CN | disclosed |
| WO-2019165358-A1 | EGFR DIMER DISRUPTORS AND USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11358965-B2 | EGFR dimer disruptors and use of the same | EGFR, ERBB2, ERBB4 | APP 4469/4885S1PR3 3890/4885S1PR1 4025/4885 |
| US-20220340572-A1 | EGFR DIMER DISRUPTORS AND USE OF THE SAME | EGFR, ERBB2, ERBB4 | APP 4469/4885S1PR3 3890/4885S1PR1 4025/4885 |
| US-11999731-B2 | EGFR dimer disruptors and use of the same | EGFR, ERBB2, ERBB4 | APP 4469/4885S1PR3 3890/4885S1PR1 4025/4885 |
| US-20200377503-A1 | EGFR DIMER DISRUPTORS AND USE OF THE SAME | EGFR, ERBB2, ERBB4 | APP 4469/4885S1PR3 3890/4885S1PR1 4025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.