Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21296585 | 0.88 | NPC1 (0.70) | P2RY14MEN1KMT2ANOTUMNPC1 | |
| SCHEMBL4855527 | 0.85 | P2RY14 (0.62) | P2RY14MEN1KMT2ANOTUMNPC1 | |
| SCHEMBL22860096 | 0.85 | P2RY14 (0.65) | P2RY14MEN1KMT2ANOTUMNPC1 | |
| SCHEMBL22590411 | 0.83 | P2RY14 (0.62) | P2RY14MEN1KMT2ANOTUMNPC1 | |
| SCHEMBL27389314 | 0.83 | MEN1 (0.76) | P2RY14MEN1KMT2ANOTUMNPC1 | |
| SCHEMBL27528745 | 0.81 | MEN1 (0.63) | P2RY14MEN1KMT2ANOTUMNPC1 | |
| SCHEMBL22870398 | 0.81 | SMN1; SMN2 (0.61) | P2RY14MEN1KMT2ANOTUMNPC1 | |
| SCHEMBL3310740 | 0.80 | MEN1 (0.63) | P2RY14MEN1KMT2ANOTUMNPC1 | |
| SCHEMBL4972667 | 0.80 | MEN1 (0.62) | P2RY14MEN1KMT2ANOTUMNPC1 | |
| SCHEMBL23081676 | 0.80 | P2RY14 (0.59) | P2RY14MEN1KMT2ANOTUMNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11999731-B2 | EGFR dimer disruptors and use of the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-06-04 | — | — | US | disclosed |
| US-20220340572-A1 | EGFR DIMER DISRUPTORS AND USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2022-10-27 | — | — | US | disclosed |
| US-11358965-B2 | EGFR dimer disruptors and use of the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-06-14 | — | — | US | disclosed |
| EP-3755323-A1 | EGFR DIMER DISRUPTORS AND USE OF THE SAME | The Regents Of The University Of Michigan (US) | 2020-12-30 | — | — | EP | disclosed |
| US-20200377503-A1 | EGFR DIMER DISRUPTORS AND USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2020-12-03 | — | — | US | disclosed |
| CN-111886009-A | EGFR dimer disruptors and uses thereof | 密歇根大学董事会 | 2020-11-03 | — | — | CN | disclosed |
| WO-2019165358-A1 | EGFR DIMER DISRUPTORS AND USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11358965-B2 | EGFR dimer disruptors and use of the same | EGFR, ERBB2, ERBB4 | P2RY14 4343/4885MEN1 3691/4885KMT2A 3794/4885 |
| US-20220340572-A1 | EGFR DIMER DISRUPTORS AND USE OF THE SAME | EGFR, ERBB2, ERBB4 | P2RY14 4343/4885MEN1 3691/4885KMT2A 3794/4885 |
| US-11999731-B2 | EGFR dimer disruptors and use of the same | EGFR, ERBB2, ERBB4 | P2RY14 4343/4885MEN1 3691/4885KMT2A 3794/4885 |
| US-20200377503-A1 | EGFR DIMER DISRUPTORS AND USE OF THE SAME | EGFR, ERBB2, ERBB4 | P2RY14 4343/4885MEN1 3691/4885KMT2A 3794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.