Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 2/20 | 0.59 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15850339 | 0.90 | ALDH1A1 (0.62) | P2RY14NOTUMMEN1KMT2AMAPT | |
| SCHEMBL22590411 | 0.85 | P2RY14 (0.62) | P2RY14NOTUMMEN1KMT2AMAPT | |
| SCHEMBL22870398 | 0.83 | SMN1; SMN2 (0.61) | P2RY14NOTUMMEN1KMT2AALDH1A1 | |
| SCHEMBL22860096 | 0.82 | P2RY14 (0.65) | P2RY14NOTUMMEN1KMT2AMAPT | |
| SCHEMBL22870899 | 0.82 | P2RY14 (0.59) | P2RY14NOTUMMEN1KMT2AMAPT | |
| SCHEMBL22590471 | 0.82 | P2RY14 (0.59) | P2RY14NOTUMMEN1KMT2AMAPT | |
| SCHEMBL4855527 | 0.80 | P2RY14 (0.62) | P2RY14NOTUMMEN1KMT2AMAPT | |
| SCHEMBL21296709 | 0.80 | P2RY14 (0.62) | P2RY14NOTUMMEN1KMT2AMAPT | |
| SCHEMBL3310740 | 0.78 | MEN1 (0.63) | P2RY14NOTUMMEN1KMT2AMAPT | |
| SCHEMBL27389314 | 0.77 | MEN1 (0.76) | P2RY14NOTUMMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021046407-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2021-03-11 | — | — | WO | disclosed |
| WO-2021046437-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2021-03-11 | — | — | WO | disclosed |