Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.44 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21296802 | 0.88 | FLT3 (0.53) | ESR1KDRFLT3ESR2MCHR1 | |
| SCHEMBL21296833 | 0.81 | ESR1 (0.47) | ESR1ESR2HRH3LTA4HHRH2 | |
| SCHEMBL21296747 | 0.79 | KDR (0.53) | KDRFLT3MCHR1LTA4HPSMB1 | |
| SCHEMBL21296824 | 0.76 | KDR (0.58) | KDRFLT3MCHR1HRH3LTA4H | |
| SCHEMBL21296770 | 0.75 | FLT3 (0.60) | KDRFLT3MCHR1BRD4JAK1 | |
| SCHEMBL21296803 | 0.74 | FLT3 (0.53) | KDRFLT3MCHR1LTA4HPSMB1 | |
| SCHEMBL21296793 | 0.74 | KDR (0.54) | KDRFLT3MCHR1HRH3LTA4H | |
| SCHEMBL21296788 | 0.74 | FLT3 (0.54) | KDRFLT3MCHR1LTA4HPSMB1 | |
| SCHEMBL21296762 | 0.72 | FLT3 (0.52) | KDRFLT3MCHR1HRH3LTA4H | |
| SCHEMBL21296810 | 0.71 | HRH3 (0.58) | MCHR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019165158-A1 | IL-6 INHIBITORS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2019-08-29 | — | — | WO | disclosed |