Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 9/20 | 0.45 |
| ▸ | JAK2 | O60674 | 8/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | CLK3 | P49761 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21296835 | 0.88 | ESR1 (0.50) | ESR1ESR2BRD4JAK1HDAC1 | |
| SCHEMBL21296799 | 0.81 | ESR1 (0.47) | ESR1ESR2JAK2BRD4JAK1 | |
| SCHEMBL21296780 | 0.79 | ADRA1D (0.54) | BRD4JAK1HDAC1LTA4HPSMB1 | |
| SCHEMBL21296795 | 0.76 | MCHR1 (0.50) | ESR1ESR2BRD4JAK1HDAC1 | |
| SCHEMBL21305117 | 0.74 | LTA4H (0.44) | ESR1HRH3LTA4HPSMB1PSMB5 | |
| SCHEMBL21296769 | 0.74 | MCHR1 (0.51) | BRD4JAK1HDAC1HRH3LTA4H | |
| SCHEMBL21296831 | 0.74 | MCHR1 (0.51) | BRD4JAK1HDAC1HRH3LTA4H | |
| SCHEMBL21296811 | 0.73 | MCHR1 (0.49) | ESR1BRD4JAK1HDAC1HRH3 | |
| SCHEMBL21296760 | 0.72 | MCHR1 (0.50) | BRD4JAK1HDAC1HRH3LTA4H | |
| SCHEMBL7332024 | 0.71 | ESR1 (0.73) | ESR1ESR2HRH3LTA4HPSMB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019165158-A1 | IL-6 INHIBITORS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2019-08-29 | — | — | WO | disclosed |