Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Acetoacetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.62 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.62 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | KDM5C | P41229 | 2/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.48 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.48 |
| ▸ | KDM6B | O15054 | 1/20 | 0.48 |
| ▸ | LDHA | P00338 | 1/20 | 0.47 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetoacetic Acid SCHEMBL28143081 | 1.00 | GLRA1 (0.62) | GLRA1SLC6A9OR51E2KDM4EKDM5C | |
| Acetoacetic Acid SCHEMBL28354276 | 0.91 | GLRA1 (0.50) | GLRA1SLC6A9OR51E2KDM4EKDM5C | |
| Acetoacetic Acid SCHEMBL649090 | 0.90 | LDHA (0.57) | GLRA1SLC6A9OR51E2KDM4EKDM5C | |
| Acetoacetic Acid SCHEMBL21402364 | 0.90 | — | — | |
| Acetoacetic Acid SCHEMBL31420005 | 0.90 | — | — | |
| Acetoacetic Acid SCHEMBL10941648 | 0.90 | LDHA (0.57) | GLRA1SLC6A9OR51E2KDM4EKDM5C | |
| Acetoacetic Acid SCHEMBL28972036 | 0.90 | LDHA (0.57) | GLRA1SLC6A9OR51E2KDM4EKDM5C | |
| Acetoacetic Acid SCHEMBL1406366 | 0.90 | LDHA (0.57) | GLRA1SLC6A9OR51E2KDM4EKDM5C | |
| Acetoacetic Acid SCHEMBL1144213 | 0.90 | LDHA (0.57) | GLRA1SLC6A9OR51E2KDM4EKDM5C | |
| Acetoacetic Acid SCHEMBL653110 | 0.90 | LDHA (0.57) | GLRA1SLC6A9OR51E2KDM4EKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3674376-B1 | CATIONIC ELECTRODEPOSITION COMPOSITION AND METHOD FOR ELECTRODEPOSITION | KANSAI PAINT CO LTD (JP) | 2024-12-11 | — | — | EP | disclosed |
| US-12043764-B2 | Cationic electrodeposition coating composition and method for electrodeposition coating | KANSAI PAINT CO., LTD. (JP) | 2024-07-23 | — | — | US | disclosed |
| US-11959188-B2 | Coating method for cationic electrodeposition coating material | KANSAI PAINT CO., LTD. (JP) | 2024-04-16 | — | — | US | disclosed |
| CN-111065700-B | Cationic electrodeposition coating composition and electrodeposition coating method | 关西涂料株式会社 | 2023-05-02 | — | — | CN | disclosed |
| EP-3757258-A1 | COATING METHOD FOR CATIONIC ELECTRODEPOSITION COATING MATERIAL | Kansai Paint Co., Ltd (JP) | 2020-12-30 | — | — | EP | disclosed |
| US-20200399777-A1 | COATING METHOD FOR CATIONIC ELECTRODEPOSITION COATING MATERIAL | KANSAI PAINT CO., LTD. (JP) | 2020-12-24 | — | — | US | disclosed |
| CN-111742084-A | Coating method of cationic electrodeposition paint | 关西涂料株式会社 | 2020-10-02 | — | — | CN | disclosed |
| US-20200283647-A1 | CATIONIC ELECTRODEPOSITION COATING COMPOSITION AND METHOD FOR ELECTRODEPOSITION COATING | KANSAI PAINT CO., LTD. (JP) | 2020-09-10 | — | — | US | disclosed |
| EP-3674376-A1 | CATIONIC ELECTRODEPOSITION COMPOSITION AND METHOD FOR ELECTRODEPOSITION | Kansai Paint Co., Ltd (JP) | 2020-07-01 | — | — | EP | disclosed |
| CN-111065700-A | Cationic electrodeposition coating composition and electrodeposition coating method | 关西涂料株式会社 | 2020-04-24 | — | — | CN | disclosed |
| WO-2019163833-A1 | COATING METHOD FOR CATIONIC ELECTRODEPOSITION COATING MATERIAL | 関西ペイント株式会社 | 2019-08-29 | — | — | WO | disclosed |