Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.34 |
| ▸ | CTSV | O60911 | 1/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | CTSH | P09668 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CASP14 | P31944 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | CASP4 | P49662 | 1/20 | 0.33 |
| ▸ | CASP5 | P51878 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | CTSZ | Q9UBR2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15830063 | 0.80 | MAPK1 (0.46) | MAPK1MAPK14BACE1BACE2KDM4E | |
| SCHEMBL21464826 | 0.80 | MAPK1 (0.39) | MAPK1MAPK14BACE1BACE2KDM4E | |
| SCHEMBL21064114 | 0.76 | CSNK1D (0.38) | MAPK1MAPK14BACE1BACE2KDM4E | |
| SCHEMBL16217357 | 0.76 | MAPK1 (0.36) | MAPK1MAPK14BACE1BACE2KDM4E | |
| SCHEMBL1343010 | 0.75 | MAPK1 (0.43) | MAPK1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL488077 | 0.73 | MAPK1 (0.44) | MAPK1MAPK14BACE1BACE2MAPK8 | |
| SCHEMBL21297220 | 0.72 | MAPK1 (0.45) | MAPK1BACE1BACE2GAKOPRL1 | |
| SCHEMBL10291039 | 0.69 | MAPK1 (0.53) | MAPK1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL30040202 | 0.69 | BACE1 (0.43) | MAPK1HDAC3HDAC1HDAC2BACE1 | |
| SCHEMBL23576766 | 0.66 | KDM4E (0.37) | CTSVPLATCTSLCTSBCTSH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10391089-B2 | PRMT5 inhibitors and uses therof | Epizyme, Inc. (US) | 2019-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10391089-B2 | PRMT5 inhibitors and uses therof | PRMT5, PRMT1, PRMT6 | MAPK1 2668/4885HDAC3 183/4885HDAC1 114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.