Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 2/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14048220 | 0.85 | EPHX2 (0.40) | EPHX2GRM4IDO1LMNACA12 | |
| SCHEMBL20462955 | 0.83 | GRM4 (0.36) | EPHX2GRM4IDO1 | |
| SCHEMBL20462954 | 0.82 | TDP1 (0.42) | EPHX2LATS1LATS2MAPTSMN1; SMN2 | |
| SCHEMBL22121588 | 0.79 | EPHX2 (0.38) | EPHX2LMNACA12CA1CA2 | |
| SCHEMBL8286072 | 0.75 | EPHX2 (0.43) | EPHX2GRM4IDO1TDO2 | |
| SCHEMBL8371409 | 0.75 | LMNA (0.58) | LMNACA12CA1CA2CA3 | |
| SCHEMBL14374698 | 0.73 | IDO1 (0.40) | IDO1KDM5ATDO2 | |
| SCHEMBL4987598 | 0.71 | EPHX2 (0.43) | EPHX2IDO1KDM5AMTNR1ATDO2 | |
| SCHEMBL2392643 | 0.71 | EPHX2 (0.43) | EPHX2IDO1LMNATDO2CYP3A4 | |
| SCHEMBL15935234 | 0.70 | EPHX2 (0.43) | EPHX2IDO1LMNAMTNR1ATDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935247-B1 | PRMT5 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2019-08-28 | — | — | EP | disclosed |