⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17300776 | 0.88 | EHMT2 (0.32) | — | |
| SCHEMBL17300773 | 0.84 | EHMT2 (0.34) | — | |
| SCHEMBL17300827 | 0.82 | EHMT2 (0.34) | — | |
| SCHEMBL17300800 | 0.81 | EHMT2 (0.35) | — | |
| SCHEMBL17300774 | 0.79 | EHMT2 (0.38) | — | |
| SCHEMBL17300802 | 0.77 | HRH4 (0.42) | — | |
| SCHEMBL19957516 | 0.73 | HCRTR1 (0.33) | — | |
| SCHEMBL15830339 | 0.73 | KCNN2 (0.35) | — | |
| SCHEMBL17300824 | 0.71 | HRH3 (0.35) | — | |
| SCHEMBL17300795 | 0.70 | HRH3 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935247-B1 | PRMT5 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2019-08-28 | — | — | EP | disclosed |