Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15830339 | 0.87 | KCNN2 (0.35) | HCRTR1HCRTR2 | |
| SCHEMBL17303810 | 0.82 | HCRTR1 (0.37) | HCRTR1HCRTR2 | |
| SCHEMBL15830010 | 0.80 | DNM2 (0.40) | HCRTR1HCRTR2 | |
| SCHEMBL17303565 | 0.79 | EHMT2 (0.37) | HCRTR1HCRTR2 | |
| SCHEMBL15834819 | 0.77 | EHMT2 (0.40) | HCRTR1HCRTR2 | |
| SCHEMBL19633485 | 0.76 | EHMT2 (0.35) | ESR1 | |
| SCHEMBL15833953 | 0.75 | EHMT2 (0.35) | ESR1 | |
| SCHEMBL19633400 | 0.74 | EHMT2 (0.36) | ESR1 | |
| SCHEMBL15833940 | 0.74 | KCNN2 (0.38) | — | |
| SCHEMBL21299883 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219465-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2023-08-02 | — | — | EP | disclosed |
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |