Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 4/20 | 0.71 |
| ▸ | LTA4H | P09960 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 9/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.50 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.50 |
| ▸ | RELA | Q04206 | 2/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL128039 | 0.83 | MPL (1.00) | MPLLTA4HRAB9AALDH1A1MAPT | |
| SCHEMBL18724008 | 0.82 | MPL (0.71) | MPLLTA4HRAB9AALDH1A1MAPT | |
| SCHEMBL17400589 | 0.82 | MPL (0.71) | MPLLTA4HRAB9AALDH1A1MAPT | |
| SCHEMBL474200 | 0.82 | MPL (0.71) | MPLLTA4HRAB9AALDH1A1MAPT | |
| SCHEMBL21007205 | 0.80 | AR (0.55) | MPLRAB9AALDH1A1MAPTNPC1 | |
| SCHEMBL474197 | 0.80 | MPL (0.78) | MPLLTA4HRAB9AALDH1A1MAPT | |
| SCHEMBL474206 | 0.79 | MPL (0.67) | MPLLTA4HRAB9AALDH1A1MAPT | |
| SCHEMBL17412697 | 0.78 | MPL (0.66) | MPLLTA4HRAB9AALDH1A1MAPT | |
| SCHEMBL17386626 | 0.78 | ALDH1A1 (0.68) | MPLLTA4HRAB9AALDH1A1MAPT | |
| SCHEMBL17386769 | 0.76 | MPL (0.63) | MPLLTA4HRAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2963036-B1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2019-08-28 | — | — | EP | disclosed |