Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 11/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.38 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17400489 | 1.00 | MPL (0.45) | MPLADORA3TRPV4PDCD1CD274 | |
| SCHEMBL17412779 | 0.92 | ADORA3 (0.42) | MPLADORA3TRPV4PDCD1CD274 | |
| SCHEMBL17412745 | 0.92 | ADORA3 (0.42) | MPLADORA3TRPV4PDCD1CD274 | |
| SCHEMBL17400648 | 0.91 | ADORA3 (0.42) | MPLADORA3TRPV4 | |
| SCHEMBL17400494 | 0.91 | MPL (0.50) | MPLADORA3TRPV4 | |
| SCHEMBL17400635 | 0.91 | MPL (0.45) | MPLADORA3TRPV4PDCD1CD274 | |
| SCHEMBL21301162 | 0.90 | MPL (0.48) | MPLADORA3TRPV4PDCD1CD274 | |
| SCHEMBL18470604 | 0.90 | MPL (0.48) | MPLADORA3TRPV4PDCD1CD274 | |
| SCHEMBL18470736 | 0.90 | ADORA3 (0.44) | MPLADORA3TRPV4PDCD1CD274 | |
| SCHEMBL17400544 | 0.90 | MPL (0.47) | MPLADORA3PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2963036-B1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2019-08-28 | — | — | EP | disclosed |