⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23761749 | 0.98 | — | — | |
| SCHEMBL24245996 | 0.92 | — | — | |
| SCHEMBL22882647 | 0.78 | — | — | |
| SCHEMBL26427122 | 0.78 | — | — | |
| SCHEMBL21698745 | 0.77 | ALDH1A1 (0.46) | — | |
| SCHEMBL22872353 | 0.77 | — | — | |
| SCHEMBL20682436 | 0.76 | — | — | |
| SCHEMBL24246075 | 0.76 | — | — | |
| SCHEMBL25729637 | 0.76 | — | — | |
| SCHEMBL12619778 | 0.73 | ALDH1A1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230127659-A1 | ANTIBODY-CONJUGATES WITH IMPROVED THERAPEUTIC INDEX FOR TARGETING HER2 TUMOURS AND METHOD FOR IMPROVING THERAPEUTIC INDEX OF ANTIBODY-CONJUGATES | SYNAFFIX B.V. (NL) | 2023-04-27 | — | — | US | disclosed |
| US-11338043-B2 | Antibody-conjugates with improved therapeutic index for targeting HER2 tumours and method for improving therapeutic index of antibody-conjugates | SYNAFFIX B.V. (NL) | 2022-05-24 | — | — | US | disclosed |
| US-20190262466-A1 | ANTIBODY-CONJUGATES WITH IMPROVED THERAPEUTIC INDEX FOR TARGETING HER2 TUMOURS AND METHOD FOR IMPROVING THERAPEUTIC INDEX OF ANTIBODY-CONJUGATES | SYNAFFIX B.V. (NL) | 2019-08-29 | — | — | US | disclosed |