Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 3/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21311632 | 1.00 | SCN9A (0.46) | SCN9AGAALMNASMN1; SMN2NPSR1 | |
| SCHEMBL21312031 | 0.86 | SMYD3 (0.50) | HTTPOLBCCR2SMYD3EPHX2 | |
| SCHEMBL21311687 | 0.81 | POLB (0.46) | SCN9AMEN1KMT2APOLBRAB9A | |
| SCHEMBL21312032 | 0.81 | POLB (0.46) | SCN9AMEN1KMT2APOLBRAB9A | |
| SCHEMBL21306731 | 0.81 | SCN9A (0.52) | SCN9ACCR2SMYD3ALDH1A1 | |
| SCHEMBL21294826 | 0.81 | SCN9A (0.55) | SCN9ACCR2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL21294795 | 0.81 | SCN9A (0.51) | SCN9ACCR2SMYD3ALDH1A1 | |
| SCHEMBL28492456 | 0.78 | SCN9A (0.49) | SCN9ACCR2ALDH1A1 | |
| SCHEMBL20096133 | 0.78 | HTR2C (0.51) | LMNAMEN1KMT2APOLBRAB9A | |
| SCHEMBL21311690 | 0.78 | HTR2C (0.51) | LMNAMEN1KMT2APOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019165290-A1 | PYRIDINE-SULFONAMIDE COMPOUNDS AND THEIR USE AGAINST PAIN AND RELATED CONDITIONS | GENENTECH, INC. (US) | 2019-08-29 | — | — | WO | disclosed |