Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 17/20 | 0.43 |
| ▸ | JAK2 | O60674 | 6/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20119571 | 1.00 | NTRK1 (0.43) | NTRK1JAK2PTPN2PTPN1SMN1; SMN2 | |
| SCHEMBL21313045 | 1.00 | NTRK1 (0.43) | NTRK1JAK2PTPN2PTPN1SMN1; SMN2 | |
| SCHEMBL21313087 | 0.89 | NTRK1 (0.41) | NTRK1JAK2PTPN2PTPN1SMN1; SMN2 | |
| SCHEMBL20119516 | 0.89 | NTRK1 (0.41) | NTRK1JAK2PTPN2PTPN1SMN1; SMN2 | |
| SCHEMBL21313088 | 0.89 | NTRK1 (0.41) | NTRK1JAK2PTPN2PTPN1SMN1; SMN2 | |
| SCHEMBL21570737 | 0.87 | PTPN2 (0.37) | NTRK1PTPN2PTPN1SMN1; SMN2POLB | |
| SCHEMBL21570757 | 0.87 | PTPN2 (0.37) | NTRK1PTPN2PTPN1SMN1; SMN2POLB | |
| SCHEMBL21313065 | 0.86 | NTRK1 (0.37) | NTRK1JAK2POLB | |
| SCHEMBL20119338 | 0.86 | NTRK1 (0.37) | NTRK1JAK2POLB | |
| SCHEMBL20119123 | 0.79 | NTRK1 (0.54) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3533796-B1 | AMINO PYRAZOLOPYRIMIDINE COMPOUND USED AS NEUROTROPHIC FACTOR TYROSINE KINASE RECEPTOR INHIBITOR | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |
| US-10829492-B2 | Amino pyrazolopyrimidine compound used as neurotrophic factor tyrosine kinase receptor inhibitor | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2020-11-10 | — | — | US | disclosed |
| US-10829492-B2 | Amino pyrazolopyrimidine compound used as neurotrophic factor tyrosine kinase receptor inhibitor | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2020-11-10 | — | — | US | disclosed |
| CN-109890820-B | Aminopyrazolopyrimidine compounds as neurotrophin tyrosine kinase receptor inhibitors | 正大天晴药业集团股份有限公司 | 2020-11-03 | — | — | CN | disclosed |
| US-20190352306-A1 | AMINO PYRAZOLOPYRIMIDINE COMPOUND USED AS NEUROTROPHIC FACTOR TYROSINE KINASE RECEPTOR INHIBITOR | LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. (CN) | 2019-11-21 | — | — | US | disclosed |
| US-20190352306-A1 | AMINO PYRAZOLOPYRIMIDINE COMPOUND USED AS NEUROTROPHIC FACTOR TYROSINE KINASE RECEPTOR INHIBITOR | LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. (CN) | 2019-11-21 | — | — | US | disclosed |
| EP-3533796-A1 | AMINO PYRAZOLOPYRIMIDINE COMPOUND USED AS NEUROTROPHIC FACTOR TYROSINE KINASE RECEPTOR INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2019-09-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10829492-B2 | Amino pyrazolopyrimidine compound used as neurotrophic factor tyrosine kinase receptor inhibitor | NTRK2, BDNF, NTRK1 | NTRK1 3/4885JAK2 291/4885PTPN2 163/4885 |
| US-20190352306-A1 | AMINO PYRAZOLOPYRIMIDINE COMPOUND USED AS NEUROTROPHIC FACTOR TYROSINE KINASE RECEPTOR INHIBITOR | NTRK2, BDNF, NTRK1 | NTRK1 3/4885JAK2 291/4885PTPN2 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.