Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | IAPP | P10997 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21317651 | 0.88 | POLB (0.58) | POLBNPSR1IAPPTRPV1FFAR1 | |
| SCHEMBL21317655 | 0.88 | POLB (0.61) | POLBNPSR1TRPV1FFAR1ALDH1A1 | |
| SCHEMBL21317656 | 0.87 | TDP1 (0.54) | POLBNPSR1FFAR1ALDH1A1GAA | |
| SCHEMBL29999191 | 0.87 | TDP1 (0.54) | POLBNPSR1FFAR1ALDH1A1GAA | |
| SCHEMBL26046421 | 0.86 | IAPP (0.57) | POLBIAPPTRPV1PRKCIALDH1A1 | |
| SCHEMBL10009025 | 0.84 | GAA (0.47) | POLBNPSR1TRPV1ALDH1A1GAA | |
| SCHEMBL26046355 | 0.82 | POLB (0.55) | POLBNPSR1TRPV1FFAR1ALDH1A1 | |
| SCHEMBL3650723 | 0.81 | TRPV1 (0.40) | POLBTRPV1ALDH1A1 | |
| SCHEMBL26046466 | 0.80 | PRKCI (0.51) | IAPPTRPV1PRKCI | |
| SCHEMBL21317653 | 0.80 | POLB (0.53) | POLBNPSR1FFAR1GAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746364-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-09-05 | — | — | US | disclosed |
| US-11746364-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-09-05 | — | — | US | disclosed |
| US-11739354-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-08-29 | — | — | US | disclosed |
| US-11739354-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-08-29 | — | — | US | disclosed |
| US-20220002769-A1 | ENZYMATIC SYNTHESIS OF KAVALACTONES AND FLAVOKAVAINS | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2022-01-06 | — | — | US | disclosed |
| US-20220002768-A1 | ENZYMATIC SYNTHESIS OF KAVALACTONES AND FLAVOKAVAINS | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2022-01-06 | — | — | US | disclosed |
| US-10941429-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2021-03-09 | — | — | US | disclosed |
| US-20190271015-A1 | ENZYMATIC SYNTHESIS OF KAVALACTONES AND FLAVOKAVAINS | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH | 2019-09-05 | — | — | US | disclosed |