Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26046416 | 0.88 | IAPP (0.45) | POLBMAPTTP53TRPV1ALDH1A1 | |
| SCHEMBL26046360 | 0.86 | POLB (0.47) | POLBNPSR1GAAFFAR4ALDH1A1 | |
| SCHEMBL21317655 | 0.83 | POLB (0.61) | POLBNPSR1TRPV1GAAALDH1A1 | |
| SCHEMBL21317652 | 0.82 | POLB (0.59) | POLBNPSR1TRPV1GAAALDH1A1 | |
| SCHEMBL26046493 | 0.82 | HMGCR (0.43) | POLBTRPV1 | |
| SCHEMBL10748552 | 0.81 | CA2 (0.39) | POLBMAPTTRPV1GAAALDH1A1 | |
| SCHEMBL21317651 | 0.81 | POLB (0.58) | POLBNPSR1TRPV1GAAALDH1A1 | |
| SCHEMBL26046352 | 0.80 | POLB (0.45) | POLBNPSR1FFAR4ALDH1A1FFAR1 | |
| SCHEMBL26046358 | 0.80 | POLB (0.50) | POLBNPSR1MAPTGAAFFAR4 | |
| SCHEMBL16319477 | 0.76 | POLB (0.55) | POLBNPSR1MAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746364-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-09-05 | — | — | US | disclosed |
| US-11739354-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-08-29 | — | — | US | disclosed |