⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20976350 | 0.87 | — | — | |
| SCHEMBL23386442 | 0.84 | ALDH1A1 (0.38) | — | |
| SCHEMBL21424835 | 0.77 | ALDH1A1 (0.37) | — | |
| SCHEMBL25455133 | 0.77 | — | — | |
| SCHEMBL25455191 | 0.76 | ALDH1A1 (0.33) | — | |
| SCHEMBL21152305 | 0.75 | — | — | |
| SCHEMBL24512593 | 0.75 | — | — | |
| SCHEMBL25455399 | 0.75 | — | — | |
| SCHEMBL19173121 | 0.75 | NAALAD2 (0.39) | — | |
| SCHEMBL15160942 | 0.73 | ALDH1A1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11041000-B2 | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases | PROTAGONIST THERAPEUTICS, INC. (US) | 2021-06-22 | — | — | US | disclosed |
| US-20210009638-A1 | PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES | PROTAGONIST THERAPEUTICS, INC. | 2021-01-14 | — | — | US | disclosed |
| US-20190270786-A1 | PEPTIDE INHIBITORS OF INTERLEUKIN-23 AND THEIR USE TO TREAT INFLAMMATORY DISEASES | PROTAGONIST THERAPEUTICS, INC. | 2019-09-05 | — | — | US | disclosed |