Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.57 |
| ▸ | PARP2 | Q9UGN5 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1870419 | 0.89 | PARP2 (0.72) | PARP1PARP2 | |
| SCHEMBL21318540 | 0.84 | PARP1 (0.79) | PARP1PARP2MEN1KMT2A | |
| SCHEMBL21318558 | 0.83 | PARP2 (0.58) | PARP1PARP2MEN1KMT2AKDM4E | |
| SCHEMBL21318523 | 0.81 | PARP1 (0.79) | PARP1PARP2 | |
| SCHEMBL21318684 | 0.80 | PARP1 (0.77) | PARP1PARP2 | |
| SCHEMBL21318543 | 0.79 | POLB (0.66) | PARP1PARP2MEN1KMT2AALDH1A1 | |
| SCHEMBL21318542 | 0.79 | PARP1 (0.64) | PARP1PARP2 | |
| SCHEMBL21318686 | 0.79 | PARP1 (0.57) | PARP1PARP2 | |
| SCHEMBL21318541 | 0.78 | PARP1 (0.58) | PARP1PARP2 | |
| SCHEMBL21318687 | 0.78 | PARP1 (0.62) | PARP1PARP2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454236-B1 | 3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXAMIDES AS PARP INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2019-09-04 | — | — | EP | disclosed |