Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 10/20 | 0.52 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 2/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20119411 | 0.88 | SMPD3 (0.43) | SMPD3IRAK4ATR | |
| SCHEMBL21319573 | 0.88 | SMPD3 (0.52) | SMPD3PRKDCJAK2JAK3IRAK4 | |
| SCHEMBL21319570 | 0.87 | SMPD3 (0.42) | SMPD3JAK2JAK3IRAK4 | |
| SCHEMBL20119441 | 0.84 | SMPD3 (0.51) | SMPD3JAK2JAK3IRAK4 | |
| SCHEMBL20119489 | 0.83 | SMPD3 (0.54) | SMPD3PRKDCJAK2JAK3IRAK4 | |
| SCHEMBL21319568 | 0.81 | SMPD3 (0.50) | SMPD3JAK2JAK3IRAK4 | |
| SCHEMBL23865295 | 0.80 | SMPD3 (0.51) | SMPD3PRKDCJAK2JAK3IRAK4 | |
| SCHEMBL20119122 | 0.80 | SMPD3 (0.51) | SMPD3PRKDCJAK2JAK3IRAK4 | |
| SCHEMBL20119364 | 0.79 | SMPD3 (0.43) | SMPD3IRAK4ATR | |
| SCHEMBL20119515 | 0.76 | MAPT (0.48) | SMPD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3533796-A1 | AMINO PYRAZOLOPYRIMIDINE COMPOUND USED AS NEUROTROPHIC FACTOR TYROSINE KINASE RECEPTOR INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2019-09-04 | — | — | EP | disclosed |