Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 4/20 | 0.34 |
| ▸ | TNF | P01375 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20017169 | 0.88 | PIK3CA (0.45) | KDM4EALDH1A1HSD17B10SMN1; SMN2HPGD | |
| SCHEMBL21321092 | 0.83 | KCNH2 (0.38) | RAB9AKDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL21320773 | 0.78 | PIK3CA (0.45) | RAB9AKDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL21321045 | 0.78 | MAP4K4 (0.40) | RAB9AARKDM4EALDH1A1HSD17B10 | |
| SCHEMBL21320925 | 0.78 | SMN1; SMN2 (0.39) | RAB9AARKDM4EALDH1A1HSD17B10 | |
| SCHEMBL21320580 | 0.76 | CYP11B1 (0.47) | RAB9AKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL21320967 | 0.75 | METAP2 (0.43) | — | |
| SCHEMBL21320774 | 0.74 | MTOR (0.43) | — | |
| SCHEMBL21320926 | 0.73 | PIK3CD (0.46) | KDM4EALDH1A1HSD17B10SMN1; SMN2HPGD | |
| SCHEMBL16796836 | 0.73 | TNF (0.48) | TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080121-B1 | FUSED TRICYCLIC BENZIMIDAZOLES DERIVATIVES AS MODULATORS OF TNF ACTIVITY | UCB BIOPHARMA SPRL (BE) | 2019-09-04 | — | — | EP | disclosed |