Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 12/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18012598 | 1.00 | KCNH2 (0.59) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| SCHEMBL21322447 | 0.86 | KCNH2 (0.45) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| SCHEMBL21322620 | 0.86 | KCNH2 (0.45) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| SCHEMBL21322635 | 0.85 | KCNH2 (0.54) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| SCHEMBL21322633 | 0.84 | KCNH2 (0.53) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| SCHEMBL19807407 | 0.82 | KCNH2 (0.62) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| SCHEMBL17022021 | 0.79 | KCNH2 (0.83) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| Hydrochloric Acid SCHEMBL17006360 | 0.78 | KCNH2 (0.83) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| SCHEMBL19807634 | 0.78 | KCNH2 (0.61) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| SCHEMBL17018775 | 0.77 | KCNH2 (0.85) | KCNH2CYP3A4CYP2C9CYP2C19TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3253766-B1 | COMPOUNDS AND METHODS FOR PREVENTING OR TREATING SENSORY HAIR CELL DEATH | UNIV WASHINGTON (US) | 2019-09-04 | — | — | EP | disclosed |