Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 12/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.49 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17022001 | 0.82 | KCNH2 (0.58) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| SCHEMBL17018729 | 0.81 | TNIK (0.59) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| SCHEMBL18220897 | 0.81 | TNIK (0.59) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| SCHEMBL5455094 | 0.80 | TNIK (0.64) | TNIKMAPTDUSP3PTPN5PTPN11 | |
| Iodide SCHEMBL17006355 | 0.80 | TNIK (0.58) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| Hydrochloric Acid SCHEMBL17006353 | 0.80 | KCNH2 (0.59) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| SCHEMBL18015730 | 0.80 | KCNH2 (0.71) | KCNH2MAPTMEN1KMT2ANPC1 | |
| SCHEMBL4234573 | 0.80 | FLT3 (0.72) | KCNH2CYP2C19MAPTMEN1KMT2A | |
| SCHEMBL21322502 | 0.78 | KCNH2 (0.59) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| SCHEMBL18220909 | 0.78 | TNIK (0.55) | KCNH2CYP3A4CYP2C9CYP2C19TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10399994-B2 | Compounds and methods for preventing or treating sensory hair cell death | UNIVERSITY OF WASHINGTON (US) | 2019-09-03 | — | — | US | disclosed |
| US-20180022756-A1 | COMPOUNDS AND METHODS FOR PREVENTING OR TREATING SENSORY HAIR CELL DEATH | FRED HUTCHINSON CANCER CENTER | 2018-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10399994-B2 | Compounds and methods for preventing or treating sensory hair cell death | CASP3, AIFM1, ATP6V1B1 | KCNH2 1453/4885CYP3A4 4809/4885CYP2C9 4564/4885 |
| US-20180022756-A1 | COMPOUNDS AND METHODS FOR PREVENTING OR TREATING SENSORY HAIR CELL DEATH | CASP3, AIFM1, ATP6V1B1 | KCNH2 1453/4885CYP3A4 4809/4885CYP2C9 4564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.