Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | MGLL | Q99685 | 6/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.39 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16963402 | 1.00 | HSD11B1 (0.44) | HSD11B1MGLLENPP2DGAT2MAPK7 | |
| SCHEMBL16963401 | 1.00 | HSD11B1 (0.44) | HSD11B1MGLLENPP2DGAT2MAPK7 | |
| SCHEMBL17310944 | 0.98 | HSD11B1 (0.42) | HSD11B1MGLLENPP2DGAT2MAPK7 | |
| SCHEMBL17310943 | 0.98 | HSD11B1 (0.42) | HSD11B1MGLLENPP2DGAT2MAPK7 | |
| SCHEMBL17310942 | 0.98 | HSD11B1 (0.42) | HSD11B1MGLLENPP2DGAT2MAPK7 | |
| SCHEMBL16962297 | 0.98 | HSD11B1 (0.42) | HSD11B1MGLLENPP2DGAT2MAPK7 | |
| SCHEMBL21323358 | 0.97 | HSD11B1 (0.42) | HSD11B1MGLLENPP2DGAT2MAPK7 | |
| SCHEMBL21323356 | 0.97 | HSD11B1 (0.42) | HSD11B1MGLLENPP2DGAT2MAPK7 | |
| SCHEMBL16963366 | 0.97 | HSD11B1 (0.42) | HSD11B1MGLLENPP2DGAT2MAPK7 | |
| SCHEMBL16963364 | 0.97 | HSD11B1 (0.42) | HSD11B1MGLLENPP2DGAT2MAPK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |