Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 4/20 | 0.56 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.56 |
| ▸ | ATXN2 | Q99700 | 5/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPK7 | Q13164 | 5/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16962303 | 1.00 | ENPP2 (0.56) | ENPP2DGAT2ATXN2HRH3MAPK8 | |
| SCHEMBL16962301 | 1.00 | ENPP2 (0.56) | ENPP2DGAT2ATXN2HRH3MAPK8 | |
| SCHEMBL16759847 | 0.94 | ENPP2 (0.50) | ENPP2DGAT2ATXN2HRH3MAPK8 | |
| SCHEMBL22911008 | 0.94 | ENPP2 (0.50) | ENPP2DGAT2ATXN2HRH3MAPK8 | |
| SCHEMBL17310934 | 0.94 | ENPP2 (0.53) | ENPP2DGAT2ATXN2HRH3LIPE | |
| SCHEMBL17310935 | 0.94 | ENPP2 (0.53) | ENPP2DGAT2ATXN2HRH3LIPE | |
| SCHEMBL16963420 | 0.94 | ENPP2 (0.53) | ENPP2DGAT2ATXN2HRH3LIPE | |
| SCHEMBL16963706 | 0.92 | ENPP2 (0.50) | ENPP2DGAT2ATXN2MAPK8MAPK10 | |
| SCHEMBL21323020 | 0.89 | ENPP2 (0.49) | ENPP2DGAT2ATXN2MAPK8MAPK10 | |
| SCHEMBL21323239 | 0.89 | ENPP2 (0.49) | ENPP2DGAT2ATXN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |