Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 6/20 | 0.42 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 4/20 | 0.40 |
| ▸ | RBP4 | P02753 | 1/20 | 0.40 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | CPS1 | P31327 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16963543 | 1.00 | GPR183 (0.42) | GPR183ITGALPROKR1RBP4ATXN2 | |
| SCHEMBL16963540 | 1.00 | GPR183 (0.42) | GPR183ITGALPROKR1RBP4ATXN2 | |
| SCHEMBL16963519 | 0.89 | GPR183 (0.40) | GPR183ITGALRBP4ATXN2ENPP2 | |
| SCHEMBL21322927 | 0.89 | GPR183 (0.40) | GPR183ITGALRBP4ATXN2ENPP2 | |
| SCHEMBL16963518 | 0.89 | GPR183 (0.40) | GPR183ITGALRBP4ATXN2ENPP2 | |
| SCHEMBL21323310 | 0.86 | GPR183 (0.54) | GPR183GAASMN1; SMN2 | |
| SCHEMBL16963765 | 0.86 | GPR183 (0.54) | GPR183GAASMN1; SMN2 | |
| SCHEMBL21323311 | 0.86 | GPR183 (0.54) | GPR183GAASMN1; SMN2 | |
| SCHEMBL16963768 | 0.86 | GPR183 (0.54) | GPR183GAASMN1; SMN2 | |
| SCHEMBL21323061 | 0.85 | ENPP2 (0.44) | GPR183ATXN2ENPP2FPR2MAPK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |