Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | GPR183 | P32249 | 8/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | MAPK7 | Q13164 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21323345 | 1.00 | ENPP2 (0.44) | ENPP2DGAT2STAT3GPR183HTR2B | |
| SCHEMBL16962991 | 1.00 | ENPP2 (0.44) | ENPP2DGAT2STAT3GPR183HTR2B | |
| SCHEMBL16962989 | 1.00 | ENPP2 (0.44) | ENPP2DGAT2STAT3GPR183HTR2B | |
| SCHEMBL16961848 | 0.98 | ENPP2 (0.46) | ENPP2DGAT2STAT3GPR183HTR2B | |
| SCHEMBL17322750 | 0.98 | ENPP2 (0.46) | ENPP2DGAT2STAT3GPR183HTR2B | |
| SCHEMBL16961853 | 0.98 | ENPP2 (0.46) | ENPP2DGAT2STAT3GPR183HTR2B | |
| SCHEMBL21985821 | 0.98 | ENPP2 (0.46) | ENPP2DGAT2STAT3GPR183HTR2B | |
| SCHEMBL16961845 | 0.98 | ENPP2 (0.46) | ENPP2DGAT2STAT3GPR183HTR2B | |
| SCHEMBL16961850 | 0.98 | ENPP2 (0.46) | ENPP2DGAT2STAT3GPR183HTR2B | |
| SCHEMBL21323342 | 0.97 | ENPP2 (0.46) | ENPP2DGAT2STAT3GPR183HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |