Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.40 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20204603 | 0.82 | KDM4E (0.71) | KDM4EALDH1A1SMN1; SMN2RECQLCYP1A2 | |
| SCHEMBL21533988 | 0.79 | EPHX2 (0.39) | KDM4EPOLB | |
| SCHEMBL22751234 | 0.75 | KDM4E (0.41) | KDM4EALDH1A1SMN1; SMN2RECQLCYP1A2 | |
| SCHEMBL270862 | 0.75 | KDM4E (0.75) | KDM4EALDH1A1SMN1; SMN2RECQLCYP1A2 | |
| SCHEMBL10202587 | 0.73 | KDM4E (0.75) | KDM4EALDH1A1SMN1; SMN2RECQLCYP1A2 | |
| SCHEMBL20347952 | 0.72 | KDM4E (0.55) | KDM4EALDH1A1SMN1; SMN2RECQLPOLB | |
| SCHEMBL17996265 | 0.72 | KDM4E (0.73) | KDM4EALDH1A1SMN1; SMN2RECQLCYP1A2 | |
| SCHEMBL22548331 | 0.71 | HTR2C (0.36) | HTR2CHTR2AHTR2B | |
| SCHEMBL20351583 | 0.69 | SCN9A (0.34) | CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL18374004 | 0.69 | SMN1; SMN2 (0.67) | KDM4EALDH1A1SMN1; SMN2CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190270756-A1 | 6-MEMBERED URACIL ISOSTERES | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2019-09-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190270756-A1 | 6-MEMBERED URACIL ISOSTERES | UNG, DUT, DPYD | KDM4E 1704/4885ALDH1A1 972/4885SMN1; SMN2 3230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.