Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21325654 | 0.87 | TLR7 (0.65) | TLR7TLR8KCNH2CYP2D6 | |
| SCHEMBL24719004 | 0.78 | TLR8 (0.69) | TLR7TLR8KCNH2CYP2D6 | |
| SCHEMBL21325598 | 0.78 | TLR8 (0.69) | TLR7TLR8KCNH2CYP2D6 | |
| SCHEMBL21325634 | 0.76 | TLR8 (0.65) | TLR7TLR8KCNH2CYP2D6 | |
| SCHEMBL24384695 | 0.76 | TLR8 (0.65) | TLR7TLR8KCNH2CYP2D6 | |
| SCHEMBL13975563 | 0.73 | KCNH2 (0.85) | TLR7TLR8KCNH2CYP2D6 | |
| SCHEMBL21325602 | 0.73 | TLR8 (0.68) | TLR7TLR8KCNH2CYP2D6 | |
| SCHEMBL21325649 | 0.73 | KCNH2 (0.85) | TLR7TLR8KCNH2CYP2D6 | |
| SCHEMBL24384587 | 0.72 | KCNH2 (0.85) | TLR7TLR8KCNH2 | |
| SCHEMBL22958997 | 0.72 | KCNH2 (0.85) | TLR7TLR8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019166532-A1 | 2,4-DIAMINOQUINAZOLINE DERIVATIVES AND MEDICAL USES THEREOF | Janssen Sciences Ireland Unlimited Company (IE) | 2019-09-06 | — | — | WO | disclosed |