SCHEMBL21335274

CC(C)C[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC(=O)[C@@H](NC(=O)[C@H](CN)NC(=O)[C@@H](NC(=O)CSC2CCCCC2)C(C)O)CCNC(=O)[C@H](C(C)O)NC(=O)[C@H](CCNc2ccc(C[C@H]3NC(=O)[C@H](CCN)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)C4CCNCC4)C(C)O)CCNC(=O)[C@H](C(C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCCN)NC(=O)[C@H](CC(C)C)NC3=O)cc2)NC(=O)[C@H](CCN)NC1=O

nearest known ligand 0.63

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	KDM1A	O60341	3/20	0.63

▸	RCOR1	Q9UKL0	2/20	0.63

▸	TERF2IP	Q9NYB0	8/20	0.40

▸	NPY1R	P25929	1/20	0.40

▸	NPY2R	P49146	1/20	0.40

▸	NPY4R	P50391	1/20	0.40

▸	NPY5R	Q15761	1/20	0.40

▸	SSTR2	P30874	5/20	0.39

▸	SSTR5	P35346	5/20	0.39

▸	DRD2	P14416	1/20	0.39

▸	SSTR4	P31391	4/20	0.39

▸	BECN1	Q14457	1/20	0.38

▸	LDHB	P07195	1/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL21335309	0.88	KDM1A (0.70)	KDM1ARCOR1TERF2IPSSTR2SSTR5
SCHEMBL21335122	0.87	KDM1A (0.79)	KDM1ARCOR1TERF2IPSSTR2SSTR5
SCHEMBL17992382	0.87	KDM1A (0.79)	KDM1ARCOR1TERF2IPSSTR2SSTR5
SCHEMBL17992399	0.84	KDM1A (0.83)	KDM1ARCOR1TERF2IPSSTR2SSTR5
SCHEMBL21335210	0.84	KDM1A (0.83)	KDM1ARCOR1TERF2IPSSTR2SSTR5
SCHEMBL21335211	0.84	KDM1A (0.83)	KDM1ARCOR1TERF2IPSSTR2SSTR5
SCHEMBL17992319	0.83	KDM1A (0.81)	KDM1ARCOR1TERF2IPSSTR2SSTR5
SCHEMBL21335248	0.83	KDM1A (0.81)	KDM1ARCOR1TERF2IPSSTR2SSTR5
SCHEMBL21335303	0.82	KDM1A (0.76)	KDM1ARCOR1TERF2IPSSTR2SSTR5
SCHEMBL21335125	0.81	KDM1A (0.83)	KDM1ARCOR1TERF2IPSSTR2SSTR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-10407467-B2	Polymyxin derivatives and their use in combination therapy together with different antibiotics	NEW PHARMA LICENCE HOLDINGS LIMITED (MT)	2019-09-10	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-10407467-B2	Polymyxin derivatives and their use in combination therapy together with different antibiotics	MRPS18A, MRPL21, RRP1B	KDM1A 3699/4885RCOR1 1566/4885TERF2IP 3714/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.