Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | FAAH | O00519 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4307000 | 0.84 | ALDH1A1 (0.78) | KDM4EMAPTFAAHPOLBALDH1A1 | |
| SCHEMBL1407210 | 0.82 | NPC1 (0.68) | KDM4EMAPTFAAHPOLBALDH1A1 | |
| SCHEMBL4308463 | 0.82 | KMT2A (0.76) | KDM4EMAPTFAAHALDH1A1SMN1; SMN2 | |
| SCHEMBL4310718 | 0.82 | KDM4E (0.68) | KDM4EMAPTFAAHPOLBALDH1A1 | |
| SCHEMBL3647856 | 0.82 | KDM4E (0.68) | KDM4EMAPTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL4311734 | 0.82 | KDM4E (0.68) | KDM4EMAPTFAAHPOLBALDH1A1 | |
| SCHEMBL4300084 | 0.81 | KDM4E (0.93) | KDM4EMAPTFAAHPOLBALDH1A1 | |
| SCHEMBL28336995 | 0.81 | POLB (0.75) | KDM4EMAPTPOLBALDH1A1LMNA | |
| SCHEMBL10076195 | 0.80 | KDM4E (0.65) | KDM4EMAPTFAAHPOLBALDH1A1 | |
| SCHEMBL20236314 | 0.80 | HTT (0.80) | KDM4EMAPTFAAHPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-B1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2019-09-11 | — | — | EP | disclosed |