Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.37 |
| ▸ | USP7 | Q93009 | 2/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.36 |
| ▸ | KDM1A | O60341 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17127857 | 1.00 | HRH4 (0.40) | HRH4LRRK2USP7PRKDCHRH3 | |
| SCHEMBL18436282 | 1.00 | HRH4 (0.40) | HRH4LRRK2USP7PRKDCHRH3 | |
| SCHEMBL18436708 | 0.90 | AOC3 (0.40) | HRH4LRRK2USP7KDM1ATDP1 | |
| SCHEMBL18436710 | 0.90 | AOC3 (0.40) | HRH4LRRK2USP7KDM1ATDP1 | |
| SCHEMBL18436183 | 0.90 | AOC3 (0.40) | HRH4LRRK2USP7KDM1ATDP1 | |
| SCHEMBL17127918 | 0.90 | AOC3 (0.40) | HRH4LRRK2USP7KDM1ATDP1 | |
| SCHEMBL17127848 | 0.87 | HRH4 (0.42) | HRH4LRRK2PRKDCHRH3KDM1A | |
| SCHEMBL21336664 | 0.87 | HRH4 (0.42) | HRH4LRRK2PRKDCHRH3KDM1A | |
| SCHEMBL18436706 | 0.87 | HRH4 (0.42) | HRH4LRRK2PRKDCHRH3KDM1A | |
| SCHEMBL17127887 | 0.87 | HRH4 (0.42) | HRH4LRRK2PRKDCHRH3KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-B1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2019-09-11 | — | — | EP | disclosed |